Overall Risk Level: 
W32.Pykspa.E is a harmful worm that can end antivirus programs on the infected computer. W32.Pykspa.E may propagate via the Skype Instant Messenger and gathers sensitive information on the compromised comptuer which it sends to a remote computer.
Alias: -
Damage Level: Low
Systems Affected: Windows
1. Temporarily Disable System Restore (Windows Me/XP). [how to]
2. Update the virus definitions.
3. Reboot computer in SafeMode [how to]
4. Run a full system scan and clean/delete all infected file(s)
5. Delete/Modify any values added to the registry. [how to edit registry]
Navigate to and delete the following registry entries:
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\policies\Explorer\Run\”[RANDOM FILE NAME]” = “[RANDOM FILE NAME].exe”
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\policies\Explorer\Run\”[RANDOM FILE NAME]” = “%Temp%\(ramdom).exe”
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\Run\”[RANDOM FILE NAME]” = “%Temp%\[RANDOM FILE NAME].exe”
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\Run\”[RANDOM FILE NAME]” = “(ramdom).exe”
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\RunOnce\”[RANDOM FILE NAME]” = “%Temp%\[RANDOM FILE NAME].exe .”
HKEY_LOCAL_MACHINE\software\Microsoft\Windows\Current Version\RunOnce\”[RANDOM FILE NAME]” = “[RANDOM FILE NAME].exe .”
HKEY_CURRENT_USER\Software\Microsoft\Windows\Current Version\Run\”[RANDOM FILE NAME]” = “%Temp%\[RANDOM FILE NAME].exe”
HKEY_CURRENT_USER\Software\Microsoft\Windows\Current Version\Run\”[RANDOM FILE NAME]” = “[RANDOM FILE NAME].exe”
HKEY_CURRENT_USER\Software\Microsoft\Windows\Current Version\RunOnce\”[RANDOM FILE NAME]” = “[RANDOM FILE NAME].exe .”
HKEY_CURRENT_USER\Software\Microsoft\Windows\Current Version\RunOnce\”[RANDOM FILE NAME]” = “%Temp%\[RANDOM FILE NAME].exe .”
Navigate to and restore the following registry entries to their previous values, if required:
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Security Center\”FirewallDisableNotify” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Security Center\”FirewallOverride” = “1″
HKEY_CURRENT_USER\Software\Microsoft\Windows\Current Version\Policies\System\”DisableRegistryTools” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Current Version\policies\system\”DisableRegistryTools” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Security Center\”UpdatesDisableNotify” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Current Version\policies\system\”EnableLUA” = “0″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Security Center\”AntiVirusDisableNotify” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Security Center\”AntiVirusOverride” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Current Version\policies\Explorer\”NoDriveTypeAutoRun” = “1″
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\Current Version\Explorer\Advanced\Folder\Hidden\SHOWALL\”CheckedValue” = “145″
6. Exit registry editor and restart the computer.
7. In order to make sure that threat is completely eliminated from your computer, carry out a full scan of your computer using AntiVirus and Antispyware Software. Another way to delete the virus using various Antivirus Program without the need to install can be done with Online Virus Scanner.
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